2,5-dibromo-N'-[4-(octyloxy)benzoyl]benzohydrazide → 2-(2,5-Dibromophenyl)-5-[4-(octyloxy)phenyl]-1,3,4-oxadiazole

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Reaction Steps

A mixture of 2,5-dibromo-N′-[4-(octyloxy)benzoyl]benzohydrazide (39.1 g, 0.0743 mol) and phosphorus oxychloride (203 mL) was refluxed for 8 hrs. Unreacted phosphorus oxychloride was distilled off and the residue poured onto crushed ice. The precipitated solid was collected by filtration and re-crystallized from EtOH/water to give 33.6 g (89% yield) 2-(2,5-dibromophenyl)-5-[4-(octyloxy)phenyl]1,3,4-oxadiazole.

Provenance & Evidence