反应详情

A mixture of 2,5-dibromo-N′-[4-(octyloxy)benzoyl]benzohydrazide (39.1 g, 0.0743 mol) and phosphorus oxychloride (203 mL) was refluxed for 8 hrs. Unreacted phosphorus oxychloride was distilled off and the residue poured onto crushed ice. The precipitated solid was collected by filtration and re-crystallized from EtOH/water to give 33.6 g (89% yield) 2-(2,5-dibromophenyl)-5-[4-(octyloxy)phenyl]1,3,4-oxadiazole.

1. temperaturewas refluxed for 8 hrs
2. distillationwas distilled off
3. additionthe residue poured
4. customonto crushed ice
5. filtrationThe precipitated solid was collected by filtration
6. customre-crystallized from EtOH/water