Benzenemethanol, alpha-(1-aminoethyl)-4-hydroxy-, hydrochloride (1:1) → t-Butyl 4-[-2-(beta-hydroxy-alpha-methyl-4-hydroxyphenethylamino)ethyl]phenoxyacetate

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Reaction Steps

The ester 20 was prepared by condensation of tert-butyl 4-[formylmethyl]phenoxyacetate (10.0 g, 0.04 mole) with α-(1-aminoethyl)-4-hydroxybenzyl alcohol 13 (8.2 g, 0.04 mole) using the same method as described for the preparation of 5, 8, and 16. The ester 20 (8.18 g, 51%) was obtained as a yellow oil.

Provenance & Evidence