反应详情

4-(2-Pyridyl)toluene, 2 mL (1.98 g, 11.7 mmol), N-bromosuccinimide (NBS), 2.5 g (14.0 mmol), and α,α′-azobis(isobutyronitrile) (AIBN), 23 mg (0.14 mmol) were suspended in 35 mL tetrachloromethane, and refluxed for 24 hours. The product was filtered, and the solvent removed from the filtrate by rotary evaporation. Equal amounts of chloroform and water were added and the product extracted. The chloroform layer was separated and dried, and the solvent removed. 4-(2-Pyridyl)benzyl bromide, 2 g, was obtained as a sticky yellow solid.

1. temperaturerefluxed for 24 hours
2. filtrationThe product was filtered
3. customthe solvent removed from the filtrate by rotary evaporation
4. additionEqual amounts of chloroform and water were added
5. extractionthe product extracted
6. customThe chloroform layer was separated
7. customdried
8. customthe solvent removed