反应详情

温度

70 °C

2 g (6.3 mmol) of 4-iodo-3-(3-nitrophenyl)-1H-pyrazole were dissolved in 20 ml of dry dimethylformamide and 2.46 g (7.5 mmol) of cesium carbonate and 0.85 ml (6.3 mmol) of p-methoxybenzyl chloride were added successively. The reaction mixture was heated at 70° C. under stirring for 5 hours. Water was then added and the product extracted with dichloromethane. The organic phase was dried over sodium sulphate and the solvent evaporated under reduced pressure. 2.4 g (86%) of the title compound crystallized from a mixture diethylether-diisopropylether.

1. extractionthe product extracted with dichloromethane
2. dry with materialThe organic phase was dried over sodium sulphate
3. customthe solvent evaporated under reduced pressure
4. custom2.4 g (86%) of the title compound crystallized from a mixture diethylether-diisopropylether