o-Xylyl bromide → HCID 759632, compound

HRID 458628Notes

Reaction equation

HRID 458628 reaction equation
[Cl:1][C:2]1[NH:11][C:10]2[C:9](=[O:12])[N:7]([CH3:8])[C:6](=[O:13])[N:5]([CH3:14])[C:4]=2[N:3]=1.[CH3:15][C:16]1[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=1[CH2:18]Br.C(Br)C1C=CC=CC=1>>[Cl:1][C:2]1[N:11]([CH2:15][C:16]2[CH:23]=[CH:22][CH:21]=[CH:20][C:17]=2[CH3:18])[C:10]2[C:9](=[O:12])[N:7]([CH3:8])[C:6](=[O:13])[N:5]([CH3:14])[C:4]=2[N:3]=1

Participants

4

Reactant 3

HCID 6992o-Xylyl bromideHCID 7498Benzyl BromideHCID 106618-Chlorotheophylline

Product 1

HCID 759632HCID 759632, compound

Procedure

From 8-Chorotheophylline (10 g, 47 mmol) and 2-methylbenzyl bromide (13.6 ml, 103 mmol). The benzyl bromide was added in two portions. First half at reaction start as described in general procedure (E), and the other half after 24 hours as the reaction had not completed.

Workup

  1. customFirst half at reaction start

Sources & evidence

ORD record
ord-85d0720b8d0b49d4b396f61203230967
Source dataset
uspto-grants-2007_03
Patent number
US07192952B2

Reaction notes

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