1-(2,4,4-Trimethylpentan-2-yl)piperidin-4-one → 4-Phenyl-8-(1-ethylpentyl)-1,4,8-triazaspiro[4.5]decan-2-one

HRID 458649Notes

Reaction equation

HRID 458649 reaction equation
CC(N1CCC(=O)CC1)(C)CC(C)(C)C.[CH2:16]([CH:18]([N:23]1[CH2:28][CH2:27][C:26](=O)[CH2:25][CH2:24]1)[CH2:19][CH2:20][CH2:21][CH3:22])[CH3:17].[NH:30]([CH2:37][C:38]([NH2:40])=[O:39])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[C:31]1([N:30]2[C:26]3([CH2:27][CH2:28][N:23]([CH:18]([CH2:16][CH3:17])[CH2:19][CH2:20][CH2:21][CH3:22])[CH2:24][CH2:25]3)[NH:40][C:38](=[O:39])[CH2:37]2)[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

Participants

4

Reactant 3

HCID 129929921-(2,4,4-Trimethylpentan-2-yl)piperidin-4-oneHCID 153703192-(Phenylamino)acetamideHCID 229374651-(1-Ethylpentyl)piperidin-4-one

Product 1

HCID 101315314-Phenyl-8-(1-ethylpentyl)-1,4,8-triazaspiro[4.5]decan-2-one

Procedure

Example 1 was repeated except that 1-(1,1,3,3-tetramethylbutyl)piperidin-4-one which was used in Example 1 was replaced with 1-(1-ethylpentyl)piperidin-4-one as obtained in Production Example 5, and 4-{[tert-butyl(diphenyl)silyl]oxy}-(2S*)-2-[(3-fluorophenyl)amino]butanam was replaced with 2-anilinoacetamide as obtained in Production Example 4, to provide the title compound.

Workup

  1. customas obtained in Production Example 5, and 4-{[tert-butyl(diphenyl)silyl]oxy}-(2S*)-2-[(3-fluorophenyl)amino]butanam
  2. customas obtained in Production Example 4

Sources & evidence

ORD record
ord-00cc0da02c384e6c8d4ca42a454b6f6f
Source dataset
uspto-grants-2007_03
Patent number
US07192964B2

Reaction notes

Loading…