Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 458649Generated: October 30, 2026

1-(2,4,4-Trimethylpentan-2-yl)piperidin-4-one → 4-Phenyl-8-(1-ethylpentyl)-1,4,8-triazaspiro[4.5]decan-2-one

https://huagongshe.com/reaction/458649

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(2,4,4-Trimethylpentan-2-yl)piperidin-4-oneHCID 12992992—
Reactant2-(Phenylamino)acetamideHCID 15370319—
Reactant1-(1-Ethylpentyl)piperidin-4-oneHCID 22937465—
Product4-Phenyl-8-(1-ethylpentyl)-1,4,8-triazaspiro[4.5]decan-2-oneHCID 10131531—

Reaction Steps

Example 1 was repeated except that 1-(1,1,3,3-tetramethylbutyl)piperidin-4-one which was used in Example 1 was replaced with 1-(1-ethylpentyl)piperidin-4-one as obtained in Production Example 5, and 4-{[tert-butyl(diphenyl)silyl]oxy}-(2S*)-2-[(3-fluorophenyl)amino]butanam was replaced with 2-anilinoacetamide as obtained in Production Example 4, to provide the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07192964B2
Source datasetuspto-grants-2007_03
ORD IDord-00cc0da02c384e6c8d4ca42a454b6f6f
Source noteuspto-grants-2007_03