HRID4587

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID702

Ethanol

C2H6O

HCID643918

2-Butenoic acid, 3-amino-, methyl ester, (2Z)-

C5H9NO2

结构：CC(=O)Nc1ccc(C(=O)OCCOC(=O)CC(=O)C=Cc2cccc([N+](=O)[O-])c2)cc1

HCID57265676

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C1=C(C)NC(C)=C(C(=O)OCCOC(=O)c2ccc(NC(C)=O)cc2)C1c1cccc([N+](=O)[O-])c1

HCID3648746

未命名化合物

收率 94%

PROCEDURE

实验过程

20 g (0.05 moles) of 2-(4-acetylaminobenzoyloxy)ethyl 2-(3-nitrobenzylidene)acetylacetate and 5.23 g (0.05 moles) of methyl 3-aminocrotonate are heated under reflux in 45 ml of ethanol for 8 hours. The solution is then cooled to room temperature to obtain 2-(4-acetylaminobenzoyloxy)ethyl 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate as a yellow powder melting at 190°-193° C. The yield is 94% of the theoretical yield.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7474294ae7e34856979084eb68096e62
来源数据集: uspto-grants-1988_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04727066
来源说明: uspto-grants-1988_02

反应 SMILES

[N+:1]([C:4]1[CH:5]=[C:6](C=C[CH:32]=1)[CH:7]=[CH:8][C:9]([CH2:11][C:12]([O:14][CH2:15][CH2:16][O:17][C:18](=[O:29])[C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:28])[CH3:27])=[CH:21][CH:20]=1)=[O:13])=O)([O-:3])=[O:2].[NH2:33]/[C:34](/[CH3:40])=[CH:35]\[C:36]([O:38][CH3:39])=[O:37].[CH2:41](O)[CH3:42]>>[CH3:41][C:42]1[NH:33][C:34]([CH3:40])=[C:35]([C:36]([O:38][CH3:39])=[O:37])[CH:9]([C:8]2[CH:7]=[CH:6][CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:32]=2)[C:11]=1[C:12]([O:14][CH2:15][CH2:16][O:17][C:18](=[O:29])[C:19]1[CH:20]=[CH:21][C:22]([NH:25][C:26](=[O:28])[CH3:27])=[CH:23][CH:24]=1)=[O:13]