反应详情

温度

100 °C

To a solution of 350 mg (1.6 mmol) of 4-ethynyl-3-(3-nitrophenyl)-1H-pyrazole in a mixture of 50 ml of dioxane and 0.5 ml (28 mmol) of water, 0.5 ml (6.5 mmol) of trifluoroacetic acid were added. The reaction was heated at 100° C. under stirring for 2 hours. The organic solvent was removed under reduced pressure and the residue partitioned between ethylacetate and aqueous sodium hydrogenocarbonate. The organic layer was then dried over sodium sulphate and evaporated to dryness, affording, after trituration with diethylether, 251 mg (68%) of the title compound.

1. additionwere added
2. customThe organic solvent was removed under reduced pressure
3. customthe residue partitioned between ethylacetate and aqueous sodium hydrogenocarbonate
4. dry with materialThe organic layer was then dried over sodium sulphate
5. customevaporated to dryness
6. customaffording