Bromoacetyl bromide → 2-[5-(3,4-Dimethoxy-benzyl)-7,8-dimethoxy-2,3-dihydro-5H-benzo[f][1,4]oxazepin-4-yl]-N-(2-ethoxy-benzyl)-acetamide
Reaction equation
Br[CH2:2][C:3](Br)=[O:4].[CH2:6]([O:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH2:11][NH2:12])[CH3:7].[CH3:17][O:18][C:19]1[CH:20]=[C:21]([CH:38]=[CH:39][C:40]=1[O:41][CH3:42])[CH2:22][CH:23]1[C:29]2[CH:30]=[C:31]([O:36][CH3:37])[C:32]([O:34][CH3:35])=[CH:33][C:28]=2[O:27][CH2:26][CH2:25][NH:24]1>>[CH3:17][O:18][C:19]1[CH:20]=[C:21]([CH:38]=[CH:39][C:40]=1[O:41][CH3:42])[CH2:22][CH:23]1[C:29]2[CH:30]=[C:31]([O:36][CH3:37])[C:32]([O:34][CH3:35])=[CH:33][C:28]=2[O:27][CH2:26][CH2:25][N:24]1[CH2:2][C:3]([NH:12][CH2:11][C:10]1[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=1[O:8][CH2:6][CH3:7])=[O:4]Participants
4
Procedure
prepared by reaction of 2-bromoacetyl bromide with 2-ethoxy-benzylamine and 5-(3,4-dimethoxy-benzyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine
Sources & evidence
- ORD record
- ord-f7931ec5d25f4353982183de8d8ac2c3
- Source dataset
- uspto-grants-2007_03
- Patent number
- US07192950B2
Reaction notes
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