2,5-Difluorobenzenesulfonyl chloride → N-(3-{4-[2-(ethylamino)pyrimidin-4-yl]-1-(4-methoxybenzyl)-1H-pyrazol-3-yl}phenyl)-2,5-difluorobenzenesulfonamide

HRID 45885Notes

Reaction equation

HRID 45885 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[C:12]([C:13]3[CH:18]=[CH:17][N:16]=[C:15]([NH:19][CH2:20][CH3:21])[N:14]=3)=[CH:11][N:10]([CH2:22][C:23]3[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[F:31][C:32]1[CH:37]=[CH:36][C:35]([F:38])=[CH:34][C:33]=1[S:39](Cl)(=[O:41])=[O:40].[Na]>N1C=CC=CC=1>[CH2:20]([NH:19][C:15]1[N:14]=[C:13]([C:12]2[C:8]([C:4]3[CH:3]=[C:2]([NH:1][S:39]([C:33]4[CH:34]=[C:35]([F:38])[CH:36]=[CH:37][C:32]=4[F:31])(=[O:41])=[O:40])[CH:7]=[CH:6][CH:5]=3)=[N:9][N:10]([CH2:22][C:23]3[CH:24]=[CH:25][C:26]([O:29][CH3:30])=[CH:27][CH:28]=3)[CH:11]=2)[CH:18]=[CH:17][N:16]=1)[CH3:21]

Participants

5

Reactant 3

HCID 27369112,5-Difluorobenzenesulfonyl chlorideHCID 5360545SodiumHCID 671848314-[3-(3-aminophenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-N-ethylpyrimidin-2-amine

Product 1

HCID 67185037N-(3-{4-[2-(ethylamino)pyrimidin-4-yl]-1-(4-methoxybenzyl)-1H-pyrazol-3-yl}phenyl)-2,5-difluorobenzenesulfonamideYield 91.8%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

340 mg (0.85 mmol) of 4-[3-(3-aminophenyl)-1-(4-methoxybenzyl)-1H-pyrazol-4-yl]-N-ethylpyrimidin-2-amine were dissolved in 10 ml of dry pyridine and 114 μl (0.85 mmol) of 2,5-difluorobenzensulfonyl chloride were added. The resulting solution was stirred at room temperature overnight. The mixture was then poured into aqueous sodium hydrogenocarbonate and extracted with dichloromethane. The organic layer was finally dried over sodium sulphate and evaporated, giving 450 mg (91%) of the title compound.

Workup

  1. extractionextracted with dichloromethane
  2. dry with materialThe organic layer was finally dried over sodium sulphate
  3. customevaporated

Sources & evidence

ORD record
ord-4bb388d729bb4bc290abe61675222a08
Source dataset
uspto-grants-2013_09
Patent number
US08541575B2

Reaction notes

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