Hydrochloric Acid → HCID 17921872, compound

HRID 458881Notes

Reaction equation

HRID 458881 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:16](=[O:17])[C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:14]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:13]1=[O:30])(C)(C)C.[ClH:32]>C(O)C>[ClH:32].[O:30]=[C:13]1[C:14]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)=[C:15]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:16](=[O:17])[N:12]1[CH2:11][CH2:10][CH2:9][CH2:8][NH2:7]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 69424216HCID 69424216, compound

Product 1

HCID 17921872HCID 17921872, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

8.2 g (<18 mmol) N-[4-(2,5-dioxo-3,4-diphenyl-2,5-dihydropyr-rol-1-yl)-butyl]-carbamic acid tert-butylester are dissolved in 80 ml ethanol and heated under reflux for two hours after addition of 4.5 ml (54 mmol) concentrated hydrochloric acid. The cooled solution is concentrated under vacuum and the residue is dried under high vacuum. The accumulated crude product is further processed without further purification: Yield 6.3 g of a yellow solid.

Workup

  1. temperatureheated
  2. temperatureunder reflux for two hours
  3. concentrationThe cooled solution is concentrated under vacuum
  4. customthe residue is dried under high vacuum
  5. customis further processed without further purification

Sources & evidence

ORD record
ord-084fa746e8ad4db2af2861e361d87547
Source dataset
uspto-grants-2007_03
Patent number
US07192967B1

Reaction notes

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