HCID 18443689, compound → HCID 58822822, compound

HRID 459103Notes

Reaction equation

[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:13])=[CH:8][CH:7]=1)[CH2:2][C:3]#[CH:4].[CH2:20]([O:22][C:23](=[O:42])[C@@H:24]([O:40][CH3:41])[CH2:25][C:26]1[CH:31]=[CH:30][C:29](OS(C(F)(F)F)(=O)=O)=[CH:28][CH:27]=1)[CH3:21]>>[CH2:20]([O:22][C:23](=[O:42])[C@@H:24]([O:40][CH3:41])[CH2:25][C:26]1[CH:31]=[CH:30][C:29]([C:4]#[C:3][CH2:2][CH2:1][O:5][C:6]2[CH:11]=[CH:10][C:9]([C:12](=[O:13])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:8][CH:7]=2)=[CH:28][CH:27]=1)[CH3:21]

Participants

Reactant 2

HCID 18443689HCID 18443689, compound

HCID 58822780HCID 58822780, compound

Product 1

HCID 58822822HCID 58822822, compound

Procedure

This compound was prepared from (4-but-3-ynyloxy-phenyl)-phenylmethanone and (2S)-2-Methoxy-3-(4-trifluoromethane-sulfonyloxy-phenyl)-propionic acid ethyl ester (Example 1, Step A) following the procedure described in Example 38, Step C (66%). 1H-NMR (200.15 MHz, CDCl3): δ 37.85–7.73 (m, 4H), 7.57–7.43 (m; 3H), 7.34 (d, 2H, J=8.1), 7.16 (d, 2H, J=8.3), 7.00 (d, 2H, J=8.6), 4.25 (t, 2H, J=7.0), 4.18 (q, 2H, J=7.0), 3.92 (dd, 1H, J=7.3, 5.6), 3.34 (s, 3H), 3.01 (s, 1H), 2.98 (d, 1H, J=3.5), 2.93 (t, 2H, J=7.0), 1.23 (t, 3H, J=7.3).

Sources & evidence

ORD record: ord-70a394b13f194d118e955f54567c8222
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07192982B2

Reaction notes

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