Trifluoromethanesulfonate → HCID 58822907, compound

HRID 459105Notes

Reaction equation

HRID 459105 reaction equation
[CH2:1]([O:5][C:6]1[CH:21]=[CH:20][C:9]2[C:10]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)=[CH:11][O:12][C:8]=2[CH:7]=1)[CH2:2][C:3]#[CH:4].C([O:24][C:25](=[O:44])[C@@H:26]([O:42][CH3:43])[CH2:27][C:28]1[CH:33]=[CH:32][C:31](OS(C(F)(F)F)(=O)=O)=[CH:30][CH:29]=1)C.[O-]S(C(F)(F)F)(=O)=O>>[F:19][C:16]1[CH:15]=[CH:14][C:13]([C:10]2[C:9]3[CH:20]=[CH:21][C:6]([O:5][CH2:1][CH2:2][C:3]#[C:4][C:31]4[CH:30]=[CH:29][C:28]([CH2:27][C@H:26]([O:42][CH3:43])[C:25]([OH:44])=[O:24])=[CH:33][CH:32]=4)=[CH:7][C:8]=3[O:12][CH:11]=2)=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 2758875TrifluoromethanesulfonateHCID 18443698HCID 18443698, compoundHCID 58822780HCID 58822780, compound

Product 1

HCID 58822907HCID 58822907, compound

Procedure

The title compound was prepared from 6-But-3-ynyloxy-3-(4-fluoro-phenyl)-benzofuran and (2S)-2-methoxy-3-(4-trifluoromethanesulfonyloxy-phenyl)-propionic acid ethyl ester Example 1, Step A) following the procedure described in Example 40, Step C. The ethyl ester derivative was contaminated with starting triflate. The mixture was hydrolyzed using the Standard Procedure C. The residue was purified by chromatography. MS(ES) for C28H23FO5 [M−H]−: 457.2.

Workup

  1. customThe residue was purified by chromatography

Sources & evidence

ORD record
ord-f0df2f06000f467fa87dbc496e621e0b
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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