4-Hydroxybiphenyl → HCID 10138800, compound

HRID 459109Notes

Reaction equation

C([O:3][C:4](=[O:22])[CH:5]([O:20][CH3:21])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19])=[CH:9][CH:8]=1)C.[C:23]1([C:29]2[CH:34]=[CH:33][C:32](O)=[CH:31][CH:30]=2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:23]1([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:28]=[CH:27][C:26]([O:19][CH2:18][CH2:17][CH2:16][CH2:15][C:14]#[C:13][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:20][CH3:21])[C:4]([OH:3])=[O:22])=[CH:12][CH:11]=2)=[CH:25][CH:24]=1

Participants

Reactant 2

HCID 71034-Hydroxybiphenyl

HCID 69424247HCID 69424247, compound

Product 1

HCID 10138800HCID 10138800, compound

Procedure

The title compound was prepared from 3-[4-(6-Hydroxy-hex-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 49, Step A) and 4-phenylphenol via the standard Mitsunobu coupling-hydrolysis procedure (Standard Procedure A) to produce the title compound. MS(ES) for C28H28O4[M+NH4]+: 446.2.

Sources & evidence

ORD record: ord-acffe9756b8046ca98956bb26eb315cd
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07192982B2

Reaction notes

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