Sodium Hydroxide → (1r*,3s*)-3-(Biphenyl-4-yloxy)-cyclohexanol

HRID 459120Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 459120
[C:1]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:6]=[CH:5][C:4]([O:7][C@H:8]2[CH2:13][CH2:12][CH2:11][C@@H:10]([O:14]C(=O)[C@@](OC)(C3C=CC=CC=3)C(F)(F)F)[CH2:9]2)=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[C:1]1([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:6]=[CH:5][C:4]([O:7][C@H:8]2[CH2:13][CH2:12][CH2:11][C@@H:10]([OH:14])[CH2:9]2)=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 58822646(1R,3S)-(2S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 3-(biphenyl-4-yloxy)-1-cyclohexyl ester

Produkt 1

HCID 58822848(1r*,3s*)-3-(Biphenyl-4-yloxy)-cyclohexanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of compound from Step D in ethanol an excess of NaOH 1N was added and the mixture reaction was stirred at room temperature. The solution was concentrated in vacuo and diluted with brine. Extracted with ether and concentrated to yield the title compound.

Aufarbeitung

  1. customthe mixture reaction
  2. concentrationThe solution was concentrated in vacuo
  3. additiondiluted with brine
  4. extractionExtracted with ether
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-fabca3168d024c9b968899996c0097b3
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07192982B2

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