p-(Trifluoromethoxy)phenol → HCID 58822828, compound

HRID 459131Notes

Reaction equation

HRID 459131 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C@H:13]([O:17][CH3:18])[C:14]([OH:16])=[O:15])=[CH:8][CH:7]=1.[F:19][C:20]([F:30])([F:29])[O:21][C:22]1[CH:27]=[CH:26][C:25](O)=[CH:24][CH:23]=1>>[CH3:18][O:17][C@@H:13]([CH2:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][O:1][C:25]2[CH:24]=[CH:23][C:22]([O:21][C:20]([F:19])([F:29])[F:30])=[CH:27][CH:26]=2)=[CH:7][CH:8]=1)[C:14]([OH:16])=[O:15]

Participants

3

Reactant 2

HCID 70015p-(Trifluoromethoxy)phenolHCID 69424952(2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid

Product 1

HCID 58822828HCID 58822828, compound

Procedure

The title compound was prepared from (2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid linked to Wang's Resin (Example 94, Step D) via Mitsunobu coupling with 4-trifluoromethoxyphenol and cleavage from the resin (Standard Procedure G) gave an oily solid.

Workup

  1. customgave an oily solid

Sources & evidence

ORD record
ord-3c734a45e19a47d39acc43cfe12b6f93
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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