Methanol → HCID 58822877, compound

Temperature

80 °C

The title compound was prepared from a solution of (2S)-3-[4-(2-Bromo-acetyl)-phenyl]-2-methoxy-propionic acid ethyl ester (0.076 mmol) from Example 124, Step C in acetonitrile (5 ml). 4-phenoxyphenol (0.152 mmol) and K2CO3 (0.23 mmol) were added. The solution was stirred for 30 min at 80° C. and then cooled to room temperature. The mixture was concentrated to dryness under vacuum and chromatographed in silica gel (hexanes/Ethyl ether 8:2 to 7:3). Fractions corresponding to the coupled compound were collected (Rf: 0.27) and concentrated to dryness. The mixture thus obtained was dissolved in 4 mL of NaOH 1N and 12 mL of Methanol and stirred at room temperature until TLC indicates the disappearance of starting material. The methanol was eliminated under vacuum and the aqueous solution diluted with 20 mL of brine and washed with diethyl ether (3×15 mL). The aqueous phase was acidulated with HCl 1N (until pH 3); extracted with ethyl acetate (3×15 mL) and the organic layer dried (MgSO4) and concentrated under vacuum. Obtained a colourless oil. 1H-NMR (200.15 MHz, CDCl3): 7.96 (d, 2H, J=8.4), 7.55–7.33 (m, 5H), 7.04–6.83 (m, 6H), 5.24 (s, 2H), 4.08 (dd, 1H, J=7.4, 4.4), 3.40 (s, 3H), 3.22 (dd, 1H, J=14.3, 4.4), 3.15 (dd, 1H, J=14.3, 7.2).

1. temperaturecooled to room temperature
2. concentrationThe mixture was concentrated to dryness under vacuum
3. customchromatographed in silica gel (hexanes/Ethyl ether 8:2 to 7:3)
4. customFractions corresponding to the coupled compound were collected (Rf: 0.27)
5. concentrationconcentrated to dryness
6. customThe mixture thus obtained
7. washwashed with diethyl ether (3×15 mL)
8. extractionextracted with ethyl acetate (3×15 mL)
9. dry with materialthe organic layer dried (MgSO4)
10. concentrationconcentrated under vacuum
11. customObtained a colourless oil

ORD record

ord-c279f7fa2e7544a29ec8a5be2f5ff2b4

Source dataset

uspto-grants-2007_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07192982B2