反应详情

A mixture of 3-(3-Benzyloxy-phenyl)-3-hydroxy-2-methoxy-propionic acid methyl ester (1 eq), mesylchloride (1 eq) triethylamine (4 eq) and a catalytic amount of DMAP (0.1 eq) in dichloromethane was stirred at room temperature overnight. The Reaction mixture was diluted with ether and washed with HCl 1N. Dried and concentrated in vacuo to give a residue which was chromatographed in silica gel to yield the title compound.

1. washwashed with HCl 1N
2. customDried
3. concentrationconcentrated in vacuo
4. customto give a residue which
5. customwas chromatographed in silica gel