3-(3-Benzyloxy-phenyl)-2-methoxy-propionic acid methyl ester → 3-(3-Hydroxy-phenyl)-2-methoxy-propionic acid methyl ester

HRID 459171Notes

Reaction equation

HRID 459171 reaction equation
[CH3:1][O:2][C:3](=[O:22])[CH:4]([O:20][CH3:21])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12]CC2C=CC=CC=2)[CH:7]=1>CO>[CH3:1][O:2][C:3](=[O:22])[CH:4]([O:20][CH3:21])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([OH:12])[CH:7]=1

Participants

3

Reactant 1

HCID 588226203-(3-Benzyloxy-phenyl)-2-methoxy-propionic acid methyl ester

Product 1

HCID 588228023-(3-Hydroxy-phenyl)-2-methoxy-propionic acid methyl ester

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3-(3-Benzyloxy-phenyl)-2-methoxy-propionic acid methyl ester in methanol was treated with a catalytic amount of C—Pd (0.1 eq) and then H2 was bubbled through the mixture and stirred overnight. The mixture reaction was concentrated and reconstituted in ethyl acetate, filtered through a pad of celite and concentrated in vacuo to give the title compound.

Workup

  1. customH2 was bubbled through the mixture
  2. customThe mixture reaction
  3. concentrationwas concentrated
  4. filtrationfiltered through a pad of celite
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b007014497684df59673d529c516778b
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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