HCID 18443617, compound → HCID 58822884, compound

HRID 459177Notes

Reaction equation

HRID 459177 reaction equation
[CH2:1]([C:4]1[CH:5]=[C:6]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][CH:22]([O:26][CH3:27])[C:23]([OH:25])=[O:24])=[CH:17][CH:16]=1)[CH:2]=[CH2:3]>C(OCC)(=O)C>[CH3:27][O:26][C@@H:22]([CH2:21][C:18]1[CH:17]=[CH:16][C:15]([O:14][CH2:13][CH2:12][CH2:11][O:10][C:9]2[CH:8]=[CH:7][C:6]([C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=3)=[CH:5][C:4]=2[CH2:1][CH2:2][CH3:3])=[CH:20][CH:19]=1)[C:23]([OH:25])=[O:24]

Participants

3

Reactant 1

HCID 18443617HCID 18443617, compound

Product 1

HCID 58822884HCID 58822884, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

3-{4-[3-(3-Allyl-biphenyl-4-yloxy)-propoxy]-phenyl}-2-methoxy-propionic acid from Example 158, Step D dissolved in ethyl acetate was treated with Pd(C) 10% under balloon pressure for 6 hours. Filtered through celite and concentrated to dryness to give the title compound.

Workup

  1. filtrationFiltered through celite and
  2. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-a2bbb973ede1493c8b112c89f2ebdb6b
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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