1,1'-Biphenyl, 4-(3-bromopropoxy)- → (2S)-3-{4-[3-(Biphenyl-4-yloxy)-propoxy]-3-methyl-phenyl}-2-methoxy-propionic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:17])[CH:5]([O:15][CH3:16])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([CH3:14])[CH:8]=1)[CH3:2].Br[CH2:19][CH2:20][CH2:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:25][CH:24]=1>>[CH2:1]([O:3][C:4](=[O:17])[C@@H:5]([O:15][CH3:16])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:19][CH2:20][CH2:21][O:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)=[CH:25][CH:24]=2)=[C:9]([CH3:14])[CH:8]=1)[CH3:2]Participants
3
Procedure
A mixture of 3-(4-Hydroxy-3-methyl-phenyl)-2-methoxy-propionic acid ethyl ester and from Step E and 4-(3-bromopropoxy)biphenyl were treated under standard condition I to give the title product.
Sources & evidence
- ORD record
- ord-bcfc0f320a894d10a9b66717efd73f3a
- Source dataset
- uspto-grants-2007_03
- Patent number
- US07192982B2
Reaction notes
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