Benzyl 4-hydroxyphenyl ketone → 2-Methoxy-3-{3-methoxy-4-[3-(4-phenylacetyl-phenoxy)-propoxy]-phenyl}-propionic acid
Reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH:13]([O:17][CH3:18])[C:14]([OH:16])=[O:15])=[CH:8][C:7]=1[O:19][CH3:20].[OH:21][C:22]1[CH:27]=[CH:26][C:25]([C:28](=[O:36])[CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[CH:24][CH:23]=1>>[CH3:18][O:17][CH:13]([CH2:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][O:21][C:22]2[CH:23]=[CH:24][C:25]([C:28](=[O:36])[CH2:29][C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)=[CH:26][CH:27]=2)=[C:7]([O:19][CH3:20])[CH:8]=1)[C:14]([OH:16])=[O:15]Participants
3
Procedure
The title compound was prepared from 3-[4-(3-Bromo-propoxy)-3-methoxy-phenyl]-2-methoxy-propionic acid (Example 175, Step B) and 1-(4-Hydroxy-phenyl)-2-phenyl-ethanone following the Standard Procedure J. MS (ES) for C28H30O7 [M+H]+: 479.
Sources & evidence
- ORD record
- ord-ec905759668a4276bc310d946b5a158a
- Source dataset
- uspto-grants-2007_03
- Patent number
- US07192982B2
Reaction notes
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