Lithium Hydroxide → HCID 10114685, compound

HRID 459202Notes

Reaction equation

C([O:3][C:4](=[O:35])[C@@H:5]([O:33][CH3:34])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([C:25](=[O:32])[C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:21][CH:20]=2)=[CH:9][CH:8]=1)C.[Li+].[OH-]>>[C:25]([C:22]1[CH:23]=[CH:24][C:19]([O:18][CH2:17][CH2:16][CH2:15][CH2:14][O:13][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:33][CH3:34])[C:4]([OH:35])=[O:3])=[CH:12][CH:11]=2)=[CH:20][CH:21]=1)(=[O:32])[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 58822813HCID 58822813, compound

Product 1

HCID 10114685HCID 10114685, compound

Procedure

The title compound was prepared from (2S)-3-{4-[4-(4-Benzoyl-phenoxy)-butoxy]-phenyl}-2-methoxy-propionic acid ethyl ester from Step A under the Standard hydrolysis procedure C. (LiOH). 1H-NMR (200.15 MHz; CDCl3): 7.81 (d, 2H, J=8.9), 7.75 (dd, 2H, J=8.3, 1.4), 7.6–7.4 (m, 3H), 7.15 (d, 2H, J=8.6), 6.81 (d, 2H, J=8.3), 4.2–3.9 (m, 5H), 3.37 (s, 3H), 3:08 (dd, 1H, J=14.2, 4.3), 2.94 (dd, 1H, J=14.2, 7.5), 2.1–1.9 (m, 4H) ppm.

Sources & evidence

ORD record: ord-f9616a1d2c754276abb3667bde95cac7
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07192982B2

Reaction notes

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