Lithium Hydroxide → HCID 58822757, compound

HRID 459203Notes

Reaction equation

C([O:3][C:4](=[O:34])[C@@H:5]([O:32][CH3:33])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:21][CH:20]=2)=[CH:9][CH:8]=1)C.[Li+].[OH-]>>[CH3:33][O:32][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]2[CH:20]=[CH:21][C:22]([O:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)=[CH:23][CH:24]=2)=[CH:11][CH:12]=1)[C:4]([OH:34])=[O:3]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 58822778HCID 58822778, compound

Product 1

HCID 58822757HCID 58822757, compound

Procedure

The title compound was prepared from (2S)-2-Methoxy-3-{4-[4-(4-phenoxy-phenoxy)-butoxy]-phenyl}-propionic acid ethyl ester, from Step A under the Standard hydrolysis procedure C. (LiOH). 1H-NMR (200.15 MHz, CDCl3): 7.4–7.2 (m, 2H), 7.15 (d, 2H, J=8.6), 7.1–6.7 (m, 9H), 4.0–3.9 (m, 5H), 3.34 (s, 3H), 3.08 (dd, 1H, J=14.0, 4.0), 2.93 (dd, 1H, J=14.0, 7.8), 2.1–1.9 (m, 4H) ppm.

Sources & evidence

ORD record: ord-a2d8884bdc11402f89cfeed84f930b6d
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07192982B2

Reaction notes

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