HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Phenylphenoxy)-1-propanol → 3-{4-[3-(Biphenyl-4-yloxy)-propoxy]-2-methoxy-phenyl}-2-methoxy-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Phenylphenoxy)-1-propanol | HCID 28351739 | — |
| Reactant | 2-(4-Hydroxy-2-methoxy-benzyl)-butyric acid methyl ester | HCID 69422796 | — |
| Reactant | HCID 178459888 | HCID 178459888 | — |
| Product | 3-{4-[3-(Biphenyl-4-yloxy)-propoxy]-2-methoxy-phenyl}-2-methoxy-propionic acid | HCID 18443634 | — |
Reaction Steps
A mixture solution of 2-(4-hydroxy-2-methoxy-benzyl)-butyric acid methyl ester from Step C and 3-(biphenyl-4-yloxy)-propan-1-ol was reacted under the Standard Mitsounobu coupling conditions B (DIAD/toluene) to give the corresponding coupled product, which afforded the title compound via the Standard hydrolysis procedure C (NaOH). MS(ES) for C26H28O6 [M+NH4]+: 454.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-b12b84db683e47bb8bab9a6733e46868 |
| Source note | uspto-grants-2007_03 |