反应详情

温度

0 °C

A mixture of 3-(4-Benzyloxy-2-chloro-phenyl)-3-hydroxy-2-methoxy-propionic acid ethyl ester (1 eq), Mesylchloride (1 eq) triethylamine (4 eq) and a catalytic amount of DMAP (0.1 eq) in dichloromethane was stirred at room temperature over night. The reaction mixture was diluted with ether and washed with HCl 1N. Dried and concentrated in vacuo to give a residue which was chromatographed in silica gel to yield a compound which was dissolved in methanol was treated with Mg (20 eq) and stirred until gas evolution was observed. Cooled to 0° C. and stirred for 4 hours. The solvent was removed and the residue reconstituted in ether washed with HCl 1N and brine and concentrated to give the title product.

1. washwashed with HCl 1N
2. customDried
3. concentrationconcentrated in vacuo
4. customto give a residue which
5. customwas chromatographed in silica gel
6. customto yield a compound which
7. stirringstirred for 4 hours
8. customThe solvent was removed
9. washwashed with HCl 1N and brine
10. concentrationconcentrated