Sodium Hydroxide → HCID 58822993, compound

HRID 459250Notes

Reaction equation

HRID 459250 reaction equation
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.[F:21][C:22]1[CH:23]=[C:24]([C:28]([C:30]2[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=2)=[O:29])[CH:25]=[CH:26][CH:27]=1.[OH-].[Na+]>>[F:21][C:22]1[CH:23]=[C:24]([CH:25]=[CH:26][CH:27]=1)[C:28]([C:30]1[CH:35]=[CH:34][C:33]([O:36][CH2:16][CH2:15][CH2:14][O:13][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:18][CH3:19])[C:4]([OH:3])=[O:20])=[CH:12][CH:11]=2)=[CH:32][CH:31]=1)=[O:29]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 11356363(3-Fluorophenyl)(4-hydroxyphenyl)methanoneHCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester

Product 1

HCID 58822993HCID 58822993, compound

Procedure

(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with (3-Fluoro-phenyl)-(4-hydroxy-phenyl)-methanone from Step A under the Standard Procedure J. The compound thus obtained was allowed to react under Standard hydrolysis procedure C (NaOH) to give the title compound. MS(ES) for C26H25FO6 [M+H]+: 453.5.

Workup

  1. customThe compound thus obtained

Sources & evidence

ORD record
ord-8e9cc91de82648809f445042b5d71575
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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