HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (2S)-3-(4-{3-[4-(3-Fluoro-benzoyl)-phenoxy]-propoxy}-phenyl)-2-methoxy-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | (3-Fluorophenyl)(4-hydroxyphenyl)methanone | HCID 11356363 | — |
| Reactant | (2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl ester | HCID 58822859 | — |
| Product | (2S)-3-(4-{3-[4-(3-Fluoro-benzoyl)-phenoxy]-propoxy}-phenyl)-2-methoxy-propionic acid | HCID 58822993 | — |
Reaction Steps
(2S)-3-[4-(3-Bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 173, Step A was treated with (3-Fluoro-phenyl)-(4-hydroxy-phenyl)-methanone from Step A under the Standard Procedure J. The compound thus obtained was allowed to react under Standard hydrolysis procedure C (NaOH) to give the title compound. MS(ES) for C26H25FO6 [M+H]+: 453.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07192982B2 |
| Source dataset | uspto-grants-2007_03 |
| ORD ID | ord-8e9cc91de82648809f445042b5d71575 |
| Source note | uspto-grants-2007_03 |