HCID 426846, compound → HCID 58822564, compound

HRID 459287Notes

Reaction equation

C([O:3][C:4](=[O:27])[C@@H:5]([O:25][CH3:26])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=2)=[CH:9][CH:8]=1)C.[CH3:28][N:29]([CH3:38])[CH2:30][CH2:31][CH2:32]OS(C)(=O)=O>>[CH3:28][N:29]([CH3:38])[CH2:30][CH2:31][CH2:32][O:24][C:21]1[CH:20]=[CH:19][C:18]([O:17][CH2:16][CH2:15][CH2:14][O:13][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:25][CH3:26])[C:4]([OH:3])=[O:27])=[CH:12][CH:11]=2)=[CH:23][CH:22]=1

Participants

Reactant 2

HCID 426846HCID 426846, compound

HCID 58822797HCID 58822797, compound

Product 1

HCID 58822564HCID 58822564, compound

Procedure

The title compound was prepared from (2S)-3-{4-[3-(4-hydroxy-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acid ethyl ester (Example 263, Step B) and methanesulfonic acid 3-dimethylaminopropyl ester (Step A) following the procedure described for Example 264. 1H-NMR (CDCl3, 200.15 MHz): δ 7.14 (d, 2H, J=7.8), 6.83–6.77 (m, 6H), 4.10–4.04 (m, 5H), 3.95–3.89 (m, 4H), 3.37 (s, 3H), 3.16–3.13 (m, 2H), 3.06–2.99 (m, 2H), 2.77 (s, 6H), 2.21–2.15 (m, 4H).

Sources & evidence

ORD record: ord-163f285d6d7b4bc8b325dd35cb1a1233
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07192982B2

Reaction notes

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