Sodium Hydroxide → HCID 58822680, compound

HRID 459293Notes

Reaction equation

C([O:3][C:4](=[O:34])[C@@H:5]([O:32][CH3:33])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)=[CH:9][CH:8]=1)C.[OH-].[Na+]>>[C:30]([C:27]1[CH:26]=[CH:25][C:24]([C:21]2[CH:20]=[CH:19][C:18]([O:17][CH2:16][CH2:15][CH2:14][O:13][C:10]3[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:32][CH3:33])[C:4]([OH:34])=[O:3])=[CH:12][CH:11]=3)=[CH:23][CH:22]=2)=[CH:29][CH:28]=1)#[N:31]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 58822894HCID 58822894, compound

Product 1

HCID 58822680HCID 58822680, compound

Procedure

The title compound was prepared from (2S)-3-{4-[3-(4′-cyano-biphenyl-4-yloxy)-propoxy]-phenyl}-2-methoxy-propionic acid ethyl ester (Step A) via the standard hydrolysis procedure C (NaOH). 1H-NMR (MeOD, 300.15 MHz): δ 7.77 (s, 4H), 7.64 (d, 2H, J=8.7), 7.18 (d, 2H, J=8.5), 7.07 (d, 2H, J=8.7), 6.86 (d, 2H, J=8.3), 4.24 (t, 2H, J=6.3), 4.17 (t, 2H, J=6.3), 3.84–3.74 (m, 1H), 3.03–2.81 (m, 2H), 2.26 (qn, 2H, J=6.0).

Sources & evidence

ORD record: ord-145d38861dfb493284801f116a674335
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07192982B2

Reaction notes

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