Sodium Hydroxide → HCID 178496732, compound

HRID 459294Notes

Reaction equation

C([O:3][C:4](=[O:37])[C@@H:5]([O:35][CH3:36])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30]4[NH:34][N:33]=[N:32][N:31]=4)=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)=[CH:9][CH:8]=1)C.[OH-].[Na+]>>[CH3:36][O:35][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30]4[NH:34][N:33]=[N:32][N:31]=4)=[CH:26][CH:25]=3)=[CH:20][CH:19]=2)=[CH:11][CH:12]=1)[C:4]([OH:37])=[O:3]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 178472545HCID 178472545, compound

Product 1

HCID 178496732HCID 178496732, compound

Procedure

The title compound was prepared from (2S)-2-methoxy-3-(4-{3-[4′-(1H-tetrazol-5-yl)biphenyl-4-yloxy]-propoxy}-phenyl)-propionic acid ethyl ester (Step A) via the standard hydrolysis procedure C (NaOH). 1H-NMR (MeOD, 300.15 MHz): δ 8.09 (d, 2H, J=8.3), 7.70 (d, 2H, J=8.3), 7.62 (d, 2H, J=8.7), 7.18 (d, 2H, J=8.5), 7.05 (d, 2H, J=8.7), 6.86 (d, 2H, J=8.7), 4.23 (t, 2H, J=6.0), 4.17 (t, 2H, J=6.1), 3.83 (dd, 1H, J=8.3, 4.2), 3.36 (s, 3H), 2.99 (dd, 1H, J=14.1, 4.0), 2.84 (dd, 1H, J=13.9, 8.1), 2.26 (qn, 2H, J=6.3).

Sources & evidence

ORD record: ord-5c8daf0dc96e4c98ba3d08c75eccca5e
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07192982B2

Reaction notes

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