Sodium Hydroxide → HCID 10273308, compound

HRID 459297Notes

Reaction equation

C([O:3][C:4](=[O:33])[C@@H:5]([O:30][CH2:31]C)[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)=[CH:20][CH:19]=2)=[CH:9][CH:8]=1)C.[OH-].[Na+]>>[CH3:31][O:30][C@@H:5]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH2:25][CH2:26][O:27][CH2:28][CH2:29]3)=[CH:20][CH:19]=2)=[CH:9][CH:8]=1)[C:4]([OH:33])=[O:3]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 69421613HCID 69421613, compound

Product 1

HCID 10273308HCID 10273308, compound

Procedure

The title compound was prepared from (2S)-2-ethoxy-3-{4-[3-(4-morpholin-4-yl-phenoxy)-propoxy]-phenyl}-propionic acid ethyl ester (Step A) by standard hydrolysis procedure C (NaOH). 1H-NMR (CDCl3, 200.15 MHz): δ 9.90 (s, 1H), 7.30 (d, 2H, J=9.1), 7.10 (d, 2H, J=8.4), 6.91 (d, 2H, J=9.1), 6.75 (d, 2H, J=8.8), 4.18–3.90 (m, 9H), 3.43–3.33 (m, 7H), 3.02 (dd, 1H, J=14.3, 4.8), 2.90 (dd, 1H, J=14.3, 7.0), 2.18 (qn, 2H, J=5.9).

Sources & evidence

ORD record: ord-ebc6b52be8e7442fa16b5539009f6316
Source dataset: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07192982B2

Reaction notes

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