3-(3-Hydroxy-phenyl)-2-methoxy-propionic acid methyl ester → 3-[3-(2-Bromo-ethoxy)-phenyl]-2-methoxy-propionic acid methyl ester

HRID 459370Notes

Reaction equation

HRID 459370 reaction equation
[CH3:1][O:2][C:3](=[O:15])[CH:4]([O:13][CH3:14])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([OH:12])[CH:7]=1.C(OC(=O)[C@@H](OC)CC1C=CC(O[CH2:29][CH2:30][Br:31])=CC=1)C>>[CH3:1][O:2][C:3](=[O:15])[CH:4]([O:13][CH3:14])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH2:29][CH2:30][Br:31])[CH:7]=1

Participants

3

Reactant 2

HCID 588228023-(3-Hydroxy-phenyl)-2-methoxy-propionic acid methyl esterHCID 58822865(2S)-3-[4-(2-bromo-ethoxy)-phenyl]2-methoxy-propionic acid ethyl ester

Product 1

HCID 694234133-[3-(2-Bromo-ethoxy)-phenyl]-2-methoxy-propionic acid methyl ester

Procedure

The title compound was prepared from 3-(3-hydroxy-phenyl)-2-methoxy-propionic acid methyl ester (Example 291, Step 4) (4.76 mol, 1000 mg) via the same procedure used for the preparation of (2S)-3-[4-(2-bromo-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 283, Step 2). MS (ES) for C13H17BrO4 [M+NH4]+: 334:2.

Sources & evidence

ORD record
ord-ab5f517588c244968e71a8f7aea16185
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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