4-Hydroxybiphenyl → 4-(2-Bromoethoxy)-1,1'-biphenyl

HRID 459397Notes

Reaction equation

HRID 459397 reaction equation
[C:1]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][C:4]([OH:7])=[CH:3][CH:2]=1.C(OC(=O)[C@@H](OC)CC1C=CC(O[CH2:27][CH2:28][Br:29])=CC=1)C>>[Br:29][CH2:28][CH2:27][O:7][C:4]1[CH:3]=[CH:2][C:1]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 71034-HydroxybiphenylHCID 58822865(2S)-3-[4-(2-bromo-ethoxy)-phenyl]2-methoxy-propionic acid ethyl ester

Product 1

HCID 41106564-(2-Bromoethoxy)-1,1'-biphenyl

Procedure

The title compound was prepared from biphenyl-4-ol via the same procedure used for the preparation of (2S)-3-[4-(2-bromo-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 283, Step 2) to produce a white solid. MS (ES) for C14H13BrO [M−H]−: 279.1.

Workup

  1. customto produce a white solid

Sources & evidence

ORD record
ord-a706c20f1f90480e95f7856cb5caa9be
Source dataset
uspto-grants-2007_03
Patent number
US07192982B2

Reaction notes

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