反应详情

The compound was synthesized starting from benzimidazol-5-amine (133 mg; 1 mmol; 1 eq.), 6-(bromomethyl)-3,4-dihydro-1,5-benzodioxepin (535 mg; 2.2 mmol; 2.2 eq.) and K2CO3 (304 mg; 2.2 mmol; 2.2 eq.) according to method 5; Yield: 0.098 g (21.4%); MS m/z: 458.5 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 2.10 (quin, 4H, 3J=5.5 Hz); 4.10 (t, 4H, 3J=5.5 Hz); 4.15 (t, 4H, 3J=5.5 Hz); 4.61 (s, 4H); 6.58-6.60 (m, 2H); 6.76-6.85 (m, 6H); 7.31 (d, 1H, 3J=9.8 Hz); 7.88 (s, 1H); 11.89 (br s, 1H); HPLC (METHOD [A]): rt 16.11 min (92.3%)

1. customThe compound was synthesized
2. customrt 16.11 min (92.3%)