反应详情

A mixture of methyl 3-chloro-4-fluoro-α-azidocinnamate (Japanese Patent Application Laid-Open No. 149723/1995) (1.85 g) and xylene (140 ml) was heated under reflux for 1 hour, and the solvent was then distilled off. The residue was purified by column chromatography on silica gel (dichloromethane) to obtain the title compound (491 mg) as colorless powder.

1. temperatureunder reflux for 1 hour
2. distillationthe solvent was then distilled off
3. customThe residue was purified by column chromatography on silica gel (dichloromethane)