huagongshe.com
HRID459547

反应详情

EQUATION

反应方程式

HRID 459547 的结构方程式

REACTANTS

反应物

2
结构：CN(C)C(=O)[C@@H]1CC[C@H](NC(=O)OCc2ccccc2)[C@@H](NC(=O)OC(C)(C)C)C1
HCID68907671

未命名化合物

结构：[H][H]
HCID178418361

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)C(=O)[C@H]1CC[C@H](N)[C@H](NC(=O)OC(C)(C)C)C1
HCID46913549

tert-Butyl [(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate

C14H27N3O3

收率 97.1%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

(1S,2S,4R)-N1-Benzyloxycarbonyl-N2-(tert-butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine (560 mg) was dissolved in tetrahydrofuran (100 ml), and 10% palladium on carbon (220 mg) was added to stir the mixture for 17 hours in a hydrogen atmosphere. After the catalyst was removed by filtration, the filtrate was concentrated to obtain the title compound (370 mg) as a colorless oil.

WORKUP

后处理

  1. customAfter the catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated