Methyl 7-chloroisoquinoline-3-carboxylate → 7-Chloroisoquinoline-3-carboxylic Acid Hydrochloride

HRID 459550Notes

Reaction equation

HRID 459550 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:12]([O:14]C)=[O:13])[N:8]=[CH:9]2)=[CH:4][CH:3]=1>Cl>[ClH:1].[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[C:7]([C:12]([OH:14])=[O:13])[N:8]=[CH:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 17842489Methyl 7-chloroisoquinoline-3-carboxylate

Product 1

HCID 574325997-Chloroisoquinoline-3-carboxylic Acid HydrochlorideYield 165.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Methyl 7-chloroisoquinoline-3-carboxylate (0.23 g) was dissolved in concentrated hydrochloric acid (10 ml) to heat the mixture for 18 hours under reflux. The temperature of the reaction mixture was dropped to room temperature, and deposits were collected by filtration and then washed with water to obtain the title compound (0.21 g) as a colorless solic.

Workup

  1. temperatureto heat the mixture for 18 hours
  2. temperatureunder reflux
  3. additionThe temperature of the reaction mixture was dropped to room temperature
  4. filtrationdeposits were collected by filtration
  5. washwashed with water

Sources & evidence

ORD record
ord-a83256ff3b564142b1366865a4c37194
Source dataset
uspto-grants-2007_03
Patent number
US07192968B2

Reaction notes

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