反应详情

To a stirred solution of ethyl 3-{[1-methyl-5-(tritylamino)pyrazol-4-yl]amino}-3-oxopropanoate (1.3 g) in tetrahydrofuran (30 ml) was added 1N aqueous sodium hydroxide solution (3.1 ml) and the mixture was stirred at room temperature for 3 hours. Tetrahydrofuran was removed in vacuo and the residue was made acidic with diluted aqueous citric acid solution. The resulting precipitate was collected by filtration and dried under reduced pressure to give 3-{[1-methyl-5-(tritylamino)pyrazol-4-yl]amino}-3-oxopropanoic acid (1.22 g).

1. customTetrahydrofuran was removed in vacuo
2. filtrationThe resulting precipitate was collected by filtration
3. customdried under reduced pressure