Potassium Hydroxide → HCID 86760461, compound

HRID 459679Notes

Reaction equation

HRID 459679 reaction equation
[CH3:1][C@@H:2]([C:8](=[O:13])[CH2:9][CH2:10][CH2:11][CH3:12])[C:3]([O:5]CC)=[O:4].[OH-].[K+]>CO>[CH3:1][C@@H:2]([C:8](=[O:13])[CH2:9][CH2:10][CH2:11][CH3:12])[C:3]([OH:5])=[O:4]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 86760462HCID 86760462, compound

Product 1

HCID 86760461HCID 86760461, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 g of Ethyl [S]-2-methyl-3-oxo-heptanoate, 0.5 g of KOH and 15 MeOH were stirred at 50° C. for 4 hrs. Then MeOH was removed and the residue is mixed with water, neutralized with conc.HCl and extracted with methylene chloride. The combined organic phase was washed with water for 3–4 times and dried over MgSO4. After evaporation of solvent, 0.8 g of product was obtained (yield 95%).

Workup

  1. customThen MeOH was removed
  2. additionthe residue is mixed with water
  3. extractionHCl and extracted with methylene chloride
  4. washThe combined organic phase was washed with water for 3–4 times
  5. dry with materialdried over MgSO4
  6. customAfter evaporation of solvent

Sources & evidence

ORD record
ord-2aefead200df48da8c9c5c0283cb1ae4
Source dataset
uspto-grants-2007_03
Patent number
US07195719B1

Reaction notes

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