Iodine → HCID 178511000, compound

HRID 459688Notes

Reaction equation

HRID 459688 reaction equation
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[NH2:11][C@H:12]([C:18]([O-:20])=[O:19])[CH2:13][CH2:14][C:15]([O-:17])=[O:16].C(O)(=O)/C=C/C(O)=O.[I:29]I>O>[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[I+2:29].[NH2:11][C@H:12]([C:18]([O-:20])=[O:19])[CH2:13][CH2:14][C:15]([O-:17])=[O:16]

Participants

5

Reactant 3

HCID 807IodineHCID 444972Fumaric AcidHCID 131726306HCID 131726306, compound

Product 1

HCID 178511000HCID 178511000, compoundYield 209%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
65 °C

Procedure

Following a method similar to example 1, 110 ml of water was added, raised the temperature up to 65° C. with stirring, added 25 g of lysine-glutamate, when dissolved completely, 3.0 g of fumaric acid was added, and 9.7 g of iodine was then introduced gradually, and the mixture was stirred for about 220 minutes, then filtrated, the filtrate was concentrated and dried to afford 33.4 g title compound.

Workup

  1. additionwas added
  2. dissolutiondissolved completely
  3. stirringthe mixture was stirred for about 220 minutes
  4. filtrationfiltrated
  5. concentrationthe filtrate was concentrated
  6. customdried

Sources & evidence

ORD record
ord-2e119693eb1d4647bac8dceb57ff07db
Source dataset
uspto-grants-2007_03
Patent number
US07195772B2

Reaction notes

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