HRID459701

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F

HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：Cc1ccc(C(NCCCC[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C(=O)O)(c2ccccc2)c2ccccc2)cc1

HCID10963195

Fmoc-Lys(Mtt)-OH

C41H40N2O4

PRODUCTS

生成物

结构：Cc1ccc(C(NCCCC[C@H](N)C(=O)O)(c2ccccc2)c2ccccc2)cc1

HCID10905507

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

2.5 gr Fmoc-Lys(Mtt)-OH was dissolved in 150 ml NMP.620 mg of HOBt was added following the addition of 1.3 gr of TBTU. Then, 3.5 gr of Rink amide resin (0.58 mmole/gr) was added and the reaction was stirred at room temperature for 3.5 hr. Then, the loaded resin was washed with NMP, MeOH, DCM and then dried in vacuum. 4.4 gr. of loaded resin was obtained.

WORKUP

后处理

washThen, the loaded resin was washed with NMP, MeOH, DCM
customdried in vacuum
customof loaded resin was obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-64a66160f4824616a88bf25379763ee3
来源数据集: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07196063B1
来源说明: uspto-grants-2007_03

反应 SMILES

[NH:1](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:2]([C:28]([OH:30])=[O:29])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:9]1[CH:15]=[CH:14][C:12]([CH3:13])=[CH:11][CH:10]=1.C1C=CC2N(O)N=NC=2C=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>CN1C(=O)CCC1>[NH2:1][C@H:2]([C:28]([OH:30])=[O:29])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[C:9]1[CH:15]=[CH:14][C:12]([CH3:13])=[CH:11][CH:10]=1