反应详情

温度

0 °C

4-(1-imidazolyl)-benzonitrile (1 g, 5.92 mmol) was dissolved in anhydrous THF (10 mL) and added drop-wise to a stirring solution of LAH-THF (1 M in THF, 18 mL) at room temperature. The reaction mixture was refluxed under Ar for 2 h and the progress was monitored by TLC. The mixture was cooled to 0° C. and quenched by drop-wise addition of a saturated Na2SO4—H2O solution. The mixture was stirred for 1 h and filtered to remove lithium salts. The filtrate was dried over anhydrous MgSO4 and concentrated to obtain 4-(1-imidazolyl)-benzylamine (0.8 g, 80%). LCMS: MH+=174.

1. temperatureThe reaction mixture was refluxed under Ar for 2 h
2. customquenched by drop-wise addition of a saturated Na2SO4—H2O solution
3. filtrationfiltered
4. customto remove lithium salts
5. dry with materialThe filtrate was dried over anhydrous MgSO4
6. concentrationconcentrated