反应详情

温度

0 °C

A stirred mixture of 2-(3-nitrophenyl)indan-1,3-dione (85 g, 0.318 mol) and hydrazine hydrate (450 ml) was heated under reflux for 2 hours then cooled to 0° C. The resulting solid was collected by filtration, washed with water (500 ml), ground to a fine powder, mixed with sufficient cold ethanol to give a thick paste, collected by filtration and dried in vacuo at 55° C. The crude solid was then recrystallised from ethanol to give 4-(3-aminobenzyl)-2H-phthalazin-1-one (32.6 g) as a pale brown solid, m.pt. 175–177° C.

1. temperaturewas heated
2. temperatureunder reflux for 2 hours
3. filtrationThe resulting solid was collected by filtration
4. washwashed with water (500 ml), ground to a fine powder
5. additionmixed with sufficient cold ethanol
6. customto give a thick paste
7. filtrationcollected by filtration
8. customdried in vacuo at 55° C
9. customThe crude solid was then recrystallised from ethanol