反应详情

4-Chloro-N-[3-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)phenyl]butyramide (1 g, 2.8 mmol) was added in portions at 0° C. to a stirred solution of sodium ethoxide [from sodium (0.15 g, 6.7 mmol)] in ethanol (10 ml), then the mixture was heated under reflux for 3 hours, cooled to ambient temperature and added to ice-water (50 ml). The resulting solid was collected by filtration, washed with water (10 ml) and dried in vacuo to give 4-[3-(2-oxopyrrolidin-1-yl)benzyl]-2H-phthalazin-1-one (0.77 g) as an off-white solid, m.pt. 206–207° C.; 250 MHz 1H-nmr (d6-DMSO) δ (ppm): 2.00 (m, 2H) (—CH2CH2CH2—), 2.55 (m-partially obscured by DMSO peak, 2H) (—NCH2—), 3.75 (t, 2H) (—COCH2—), 4.3 (s, 2H) (ArCH2—), 7.05 (d, 1H) (ArH), 7.25 (t, 1H) (ArH), 7.5 (d, 1H) (ArH), 7.7 (s, 1H) (ArH), 7.75–8.0 (m, 3H) (3×ArH), 8.25 (d, 1H) (ArH); m/z (M+H)+. 320, 100% purity.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 3 hours
3. filtrationThe resulting solid was collected by filtration
4. washwashed with water (10 ml)
5. customdried in vacuo