Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 135749051 | HCID 135749051 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22930992 | HCID 22930992 | — |
Reaction Steps
To a DMF solution of methyl 6-(3-ethyl-4-hydroxyphenyl)pyridine-2-carboxylate were added potassium carbonate and methyl iodide, and the whole was stirred at an oil bath temperature of 70° C. for 2 hours to obtain methyl 6-(3-ethyl-4-methoxyphenyl)pyridine-2-carboxylate, which was then stirred in methanol and a 1M aqueous sodium hydroxide solution at an oil bath temperature of 60° C. for 1 hour to obtain an objective compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07196080B2 |
|---|
| Source dataset | uspto-grants-2007_03 |
|---|
| ORD ID | ord-10dbe7851b4847caaa231be48043a41b |
|---|
| Source note | uspto-grants-2007_03 |
|---|
