Methyl iodide → HCID 22930992, compound

HRID 459845Notes

Reaction equation

HRID 459845 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([C:10]2[N:15]=[C:14]([C:16]([O:18][CH3:19])=[O:17])[CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:7][C:8]=1[OH:9])[CH3:2].[C:20](=O)([O-])[O-].[K+].[K+].CI>CN(C=O)C>[CH2:1]([C:3]1[CH:4]=[C:5]([C:10]2[N:15]=[C:14]([C:16]([O:18][CH3:19])=[O:17])[CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:20])[CH3:2]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 135749051HCID 135749051, compound

Product 1

HCID 22930992HCID 22930992, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
70 °C

Procedure

To a DMF solution of methyl 6-(3-ethyl-4-hydroxyphenyl)pyridine-2-carboxylate were added potassium carbonate and methyl iodide, and the whole was stirred at an oil bath temperature of 70° C. for 2 hours to obtain methyl 6-(3-ethyl-4-methoxyphenyl)pyridine-2-carboxylate, which was then stirred in methanol and a 1M aqueous sodium hydroxide solution at an oil bath temperature of 60° C. for 1 hour to obtain an objective compound.

Sources & evidence

ORD record
ord-10dbe7851b4847caaa231be48043a41b
Source dataset
uspto-grants-2007_03
Patent number
US07196080B2

Reaction notes

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