Trifluoroacetic acid → 2-(2-(N-Cyclopropyl-4-methoxy-2,6-dimethylphenylsulfonamido)ethoxy)acetic acid

Participants

Reaction Conditions

Reaction Steps

To a dichloromethane solution (10 ml/mmol) of tert-butyl 2-(2-(N-cyclopropyl-4-methoxy-2,6-dimethylphenylsulfonamido)ethoxy)acetate (1 equiv.) was added TFA (13 equiv.) at 0° C. and the resulting reaction mixture was stirred at 25° C. for 2 h. The solvent was evaporated off and the product dried under vacuum to remove traces of TFA. The crude acid was used directly for the next step without any further purification.

Provenance & Evidence